Posts Tagged Macular degeneration

New Research on Vitamins May Reduce Macular Degeneration

As the population ages, Age-Related Macular Degeneration (AMD) is becoming more prevalent. Two recent studies about different vitamins may hold the answer to managing and slowing down the deleterious effects of this serious disease.

The first study shows that people with increased levels of vitamin D are less likely to have an early onset of this sight-threatening condition.  In this study, women who consumed the most vitamin D had a 59 percent lower risk of developing AMD, compared to age-matched women who took in the least vitamin D.

macular generation photoVitamin D is available in many foods and  is produced naturally by your body during exposure to the sun’s UV rays.  Still, many experts recommend taking a daily supplement to increase your vitamin D levels.

Meanwhile, scientists at Columbia University are trying to slow down the progrrssion of AMD by slowing down the buildup of vitamin A in the eye.

In order for the retina to process light, vitamin A has to undergo a series of chemical transformations, which often causes the vitamin to form ‘clumpy’ deposits. These deposits are the basis of AMD.

Now a team at the department of ophthalmology at Columbia’s Harkness Eye Institute, have synthesized a modified vitamin A drug.  By feeding this artificial vitamin A to healthy mice, the experts were able to reduce the amount of vitamin A deposits without any noticeable side effects. These findings may eventually help to reduce the risk of, and in some cases stop, the condition in its tracks.

While these two studies show hope in the treatment of AMD, until more concrete results are produced patients need to take the condition seriously. Anyone with a family history of Macular Degeneration should visit their optometrist yearly for a comprehensive eye exam. If your eye doctor has seen early signs of AMD, your may need to be seen more frequently.

 

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Omega-3 Fatty Acids Can Help Prevent Several Forms of Blindness

It has long been known that Omega-3 fatty acids can help to prevent some forms of blindness – and now researchers have found out exactly how they provide that protection.

The findings, published in the February 9th issue of Science Translational Medicine, demonstrate the protective mechanism of Omega-3′s. These fatty acids have a direct effect on blood vessel growth that selectively promotes the growth of healthy blood vessels and inhibits the growth of abnormal vessels.

This is good news for those with retinopathy, an eye disease that’s caused by the proliferation of leaky blood vessels in the retina, which is also the leading cause of blindness in America.

The study also suggests that Omega-3′s may be beneficial in the treatment of two other widespread diseases—diabetes, which is a disease that affects 4.1 million Americans and is expected to triple in the next 40 years, and age-related macular degeneration (AMD), a disease that currently affects more than seven million Americans and will only increase as our population ages. The less common but more severe type of AMD, the wet form, is also caused by abnormal blood vessel growth.

The ability to prevent these abnormal blood vessels with Omega-3 fatty acids could provide tremendous cost savings, says ophthalmologist Lois Smith, MD, PhD, senior investigator on the study. “The cost of Omega-3 supplementation is about $10 a month, versus up to $4,000 a month for anti-VEGF therapy,” she says, referring to drugs such as Macugen and Lucentis used in AMD and diabetic retinopathy. “Our new findings give us new information on how Omega-3s work that makes them an even more promising option.”

Omega-3 fatty acids are usually highly concentrated in the retina, but they’re often lacking in Western diets.  You should aim to get at least one rich source of Omega-3 fatty acids in your diet every day. This could be through a serving of fatty fish, such as salmon, a tablespoon of canola or soybean oil in salad dressing or in cooking, or a handful of walnuts or ground flax seed mixed into your morning oatmeal.

For people who don’t eat fish or other foods rich in Omega-3 fatty acids, you should begin taking an Omega-3 supplement of 500 mg per day. And those taking aspirin and acetaminophen shouldn’t worry—the study provided reassurance that taking these drugs doesn’t reduce the benefits of Omega-3’s.

This information is brought to you by Clarin Eye Care Center. Please call or contact our office for more information.

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Macular Degeneration Is Actually Decreasing Despite An Aging Population

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The number of Americans with Age-Related Macular Degeneration (ARMD) has been decreasing lately, despite what experts have warned for years.  Researchers are unsure, but believe this is because of healthier lifestyles.

“The decreasing prevalence of ARMD may reflect recent changes in the frequency of smoking and other exposures such as diet, physical activity, and blood pressure associated with ARMD,” the researchers stated  in their paper.

With increased life expectancy and an increase in the number of baby boomers, we’ve been expecting a rise in this potentially vision threatening disease.

The  prevalence of ARMD among adults age 40 and older was an estimated 6.5 percent today, which represented a decrease by a whopping 30.8% compared to 1988-1994.

This is, of course, good news as ARMD is one of the nations leading causes of vision loss affecting millions of Americans.  Macular Degeneration has a large genetic component so it’s important for you to try to find out your family history and get your eyes checked frequently.

The only management for the most common ‘dry’ form ARMD is certain nutritional suppliments, antioxidents and omega-3 fatty acids.  This has only been shown to slow the progress of the disease.

For the more severe ‘wet’ form, anti-VEGF injections directly into the eye have shown some improvement in vision.

This information is brought to you by Clarin Eye Care, a family Optometry practice in Palmetto Bay, Florida.  Please call or contact our office for more information.

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Stem Cell Trial for AMD Approved

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By John Gever, Senior Editor, MedPage Today
Published: January 06, 2011

A clinical trial of a human embryonic stem cell (ESC) therapy for age-related macular degeneration has been approved by the FDA, making it the first such study for a common disease.

Advanced Cell Technology, based in Marlborough, Mass., said it had received the agency’s clearance to begin a phase I/II trial in 12 patients with age-related “dry” macular degeneration, which affects about 10 to 15 million people in the U.S.

Patients will receive implants with retinal pigment epithelial (RPE) cells derived from the company’s ESC lines.

Other clinical trials of ESC-based therapies are under way or approved to begin, but they have been for comparatively rare conditions: certain severe spinal cord injuries and Stargardt’s macular dystrophy, a childhood-onset form of blindness that resembles age-related macular degeneration.

Advanced Cell Technology is also conducting the latter trial, using the same ESC-derived RPE cells. The two studies will run simultaneously, the company said.

In a statement, the company’s chief scientific officer, Robert Lanza, MD, said that 50,000 to 200,000 cells would be implanted beneath the retina in each patient in the open-label macular degeneration trial.

The relatively small cell numbers mean “manufacturing and distribution of the therapeutic product is scalable,” Lanza said.

Studies with its lab-grown RPE cells in rodent models of macular degeneration and Stargardt’s disease have demonstrated improvements in visual function, according to the company.

Both clinical trials are designed primarily to assess safety and tolerability.

Clinical sites for the macular degeneration study have not yet been finalized, but Advanced Cell Technology listed centers at UCLA and Stanford as under consideration.

This information is brought to you by Clarin Eye Care, a family Optometry practice in Palmetto Bay, Florida.  Please call or contact our office for more information.

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Healthy Habits Can Cut Your Risk of Eye Disease

A new study has suggested that women who exercise, eat right, and don’t smoke can possibly cut their risk of developing age-related macular degeneration (AMD) by more than two-thirds.

The authors wrote:

Adopting these healthy habits may markedly lower the prevalence of early AMD, the number of people who develop advanced AMD in their lifetime, and healthcare costs associated with treatment for this condition.

Participants in the study previously gave researchers a detailed dietary and lifestyle history about six years before AMD was assessed, making them ideal to look at to examine links between behavioral factors and AMD,  a leading cause of vision loss among U.S. adults ages 60 and older.

Self-reported diets at baseline were scored according to the content of relatively healthy foods, such as whole grains, vegetables and fruits, and milk, as well as unhealthy foods including saturated fats, sodium, and added sugar.

Responses to questionnaire items on recreational and household physical activity were translated into estimated energy expenditures, expressed as metabolic energy task-hours (MET-hours) per week.

Lowered associations with AMD risk were found to be statistically significant for both diet and exercise. Interestingly, smoking by itself was not a particularly strong risk factor for AMD in this study. Compared with participants who never smoked.

But all three factors combined were a powerful indicator of AMD risk  ompared to women who practiced good diet and exercise habits.

The observational study provided no hard evidence for a causal mechanism, but the researchers suggested that healthy lifestyles may keep blood pressure down, which, in turn, could reduce AMD risk.

Behavioral factors can also affect the composition of macular pigment which potentially makes the macula more or less vulnerable to various pathologies such as oxidative damage – which causes AMD.

This information is brought to you by Clarin Eye Care, a family Optometry practice in Palmetto Bay, Florida.  Please call or contact our office for more information.

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Eye Care Is More Than Just Blurry Vision

The fear of going blind is a scary thought in most people’s minds.  However, Lighthouse International conducted a new survey showing six out of seven people that are at risk for, or who currently have, eye disease do not get annual eye exams.

Some of the reasons people may forgo eye care is the cost, the fear of hearing a worst case scenario from the doctor or because they don’t experience any trouble with their vision.  Of course if you wait until you experience a change in your vision, you can miss an early diagnosis of a possibly treatable or manageable disease.

For example, glaucoma and macular degeneration are two of the most common eye diseases.  Both of these have almost no symptoms early on — but can cause partial blindness and a loss of function in your life.  Both are also manageable, especially if they are discovered early.

These conditions are also much more likely to occur if there is a family history, so talking to your relatives and being proactive in your eye care are the two greatest things you can do.  You should see an eye doctor annually if someone in your family has been diagnosed with glaucoma or macular degeneration.

Vision loss, however, isn’t the only issue. A routine eye exam can also detect many other diseases in their early stages, including diabetes, autoimmune disorders, neurofibromatosis and even brain tumors.

Routine eye exams should be performed every year for those 40 and older, not just to check for blurry vision but to make sure your eyes, and body, are healthy. Call our office today to schedule the next step in your preventative medical care.

This information is brought to you by Clarin Eye Care Center. Please call or contact our office for more information.

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